ASBMR 2025 Annual Meeting Recordings

Recorded On: 09/05/2025

Recordings from the ASBMR 2025 Annual Meeting Recordings

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Society Update, Esteemed Awards Presentations and Gerald D. Aurbach Lecture
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Open to view video. Gordana Vunjak-Novakovic PhD
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Rare Bone Diseases Pre-Meeting Session 1- Skeletal Dysplasias
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Open to view video. Erik Imel MD, MS, Luis Fernandez De Castro PhD, Alison Boyce, MD, Ravi Savarirayan, Klaus Engelke Erik Imel MD, MS Introduction & Overview Luis Fernandez De Castro PhD Osteoclast-Osteoblast Feedback in Fibrous Dysplasia: Insights from Bench and Bedside Alison Boyce MD Novel Treatment Approaches in Fibrous Dysplasia Ravi Savarirayan New, Disruptive Precision Therapies for Achondroplasia: Changing the Rules of the Game Klaus Engelke Effect of Long-Term Vosoritide Treatment in Pediatric Participants With Achondroplasia on Bone Mineral Density and Bone Content: Results From Quantitative Computed Tomography Analyses
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Rare Bone Diseases Pre-Meeting Session 2: Disorders of Ectopic Mineralization
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Open to view video. David Weber MD, Kelly Roszko, Edward Hsiao MD, PhD, Eva Liu MD, Imranul Alam David Weber MD Overview of the Pathophysiology of ENPP1 Deficiency Kelly Roszko Hyperphosphatemic Familial Tumoral Calcinosis: Defining Mechanisms to Inform Treatment Edward Hsiao MD, PhD Emerging Therapies for Fibrodysplasia Ossificans Progressive Eva Liu MD XLH and Enthesopathy Imranul Alam Vantictumab, an anti-FZD antibody, Rescues the Osteopetrotic Bone Phenotype in Heterozygous ADO Mice
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Rare Bone Diseases Pre-Meeting Session 3: Prevention of Muscle and Bone Loss
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Open to view video. Roland Baron DDS, PhD, Eric Hoffman, Pat Furlong BSN, MS, Amy Sato Roland Baron DDS, PhD Mechanisms of Carpo-Tarsal Osteolysis from Pre-Clinical Models Eric Hoffman Clinical studies of vamorolone: An anti-inflammatory corticosteroid with unique structure/activity relationships: not metabolized by HSD11B's, and a MR antagonist Pat Furlong BSN, MS Navigating Advocacy for Individuals with Duchenne Muscular Dystrophy in an Ever-Broadening Therapeutic Landscape Amy Sato Duchenne Muscular Dystrophy leads to Concurrent Muscle and Bone Disease with a Loss of Osteoblastic Bone Cell Populations
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Rare Bone Diseases Pre-Meeting Session 4: From the Genome to the Lived Experience
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Open to view video. Kenneth Kozloff PhD, Frank Rauch MD, Colleen Gioffreda, Tracy Hart Kenneth Kozloff PhD Anti-Sclerostin Antibody for the Treatment of Osteogenesis Imperfecta Frank Rauch MD Expanding Molecular Diagnoses in Rare Bone Disorders Colleen Gioffreda Achondroplasia Tracy Hart The Importance of Partnerships in Rare Bone Disease Research
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Plenary Symposium: NIDDK 75th Anniversary Session - Past, Present, and Future of Research on the Bone-Parathyroid-Kidney Axis
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Open to view video. Gregory Germino MD, Henry Kronenberg MD, Nicola Partridge PhD, Sharon Moe MD, Cheryl Ackert-Bicknell PhD, Jordan Matz, Ryan Tiu Gregory Germino MD 75 Years of Discovery, and So Much More to Come! Henry Kronenberg MD How PTH Regulates the Lineage Pathways to Osteoblasts Nicola Partridge PhD Basic Aspects of PTH Action in Osteoblasts Sharon Moe MD CKD-MBD Cheryl Ackert-Bicknell PhD Response to PTH Anabolic Action is Genetic and Anatomically Site-Specific in Mice Jordan Matz Zinc Fingers and Homeoboxes 2 (ZHX2) Exerts Sex-Specific Differences in Chronic Kidney Disease - Associated Skeletal Adaptations Ryan Tiu Value of Machine Learning as a Predictor of Bone Pathology in Pediatric Chronic Kidney Disease-Mineral and Bone Disorder Patients Utilizing Biomarkers and Anthropometric Parameters
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Plenary Symposium: Anabolic Therapies for Osteoporosis - Can We Achieve a Cure?
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Open to view video. Luyao Wang PhD, Serge Ferrari MD, Elena Tsourdi MD Luyao Wang PhD New Discoveries: Aptamers to Block Specific Loops of Sclerostin Serge Ferrari MD Why Do Anabolic Effects Wane? Elena Tsourdi MD Important Clinical Questions Regarding Non-responders and Anabolic Sequential Therapies
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Oral Presentations: Uncommon Skeleton: Bench Discoveries in Rare Bone Disorders
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Open to view video. Ann Zovein MD, Sanja Novak PhD, Franceska Kovaci, Jakob Hoeppner MD, Jiachen Lin MD, PhD Ann Zovein MD AGA2115, a Bispecific Antibody Neutralizing Both Dickkopf-1 (DKK1) and Sclerostin Increased Bone Formation and Decreased Bone Resorption Resulting in Significant Gains in Bone Mass and Strength in Nonhuman Primates (NHPs) Sanja Novak PhD Skeletal stem/progenitor engraftment is dependent on bone marrow niche Franceska Kovaci Cellular origin of spine deformity in a mouse model of Neurofibromatosis Type 1 Jakob Hoeppner MD Mutations in Helix 8 of the PTH1R cause a novel skeletal dysplasia syndrome by altering receptor engagement with effector proteins Jiachen Lin MD, PhD Genetic Perturbation of TRPV4 Alters the Cell Fate of Chondrogenic Lineage and Causes Hypoplasia of Intervertebral Disc in Human and Mice
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Oral Presentations: Treatments of Rare Bone Diseases
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Open to view video. Eric Orwoll MD, Iris Hartley MD, Mishaela Rubin MD, Leanne Ward MD, FRCPC, Harveen Natarajan PhD Eric Orwoll MD AGA2115, a Bispecific Antibody Neutralizing DKK1 and Sclerostin, Increased Bone Formation, Decreased Bone Resorption, and Led to Significant BMD Gains in a First-in-Human, Single- and Multiple-dose, Placebo-Controlled Randomized Study Iris Hartley MD The Oral Calcilytic Encaleret Reduced Urinary Calcium While Maintaining Blood Calcium in Individuals with Post-Surgical Hypoparathyroidism Mishaela Rubin MD Improved Skeletal Dynamics in Adults Treated with Palopegteriparatide for Chronic Hypoparathyroidism: 214-Week Results from the Phase 2 PaTH Forward Trial Leanne Ward MD, FRCPC Improvements in Lower Extremity Alignment are Associated with Physical Functioning in Children With Achondroplasia Treated With Navepegritide: 52-Week Results From the ApproaCH Trial Harveen Natarajan PhD Phase 1 Trial in Healthy Participants of KER-065, Modified Activin Receptor Ligand Trap, Support Development in Duchenne Muscular Dystrophy (DMD) and Bone Disorders
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Oral Presentations: Secondary Prevention in Fractures
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Open to view video. Richard Eastell, Dana Bliuc, Mike Lin, Junko Tamaki, Sharon Chou MD Richard Eastell The Number Needed to Treat (NNT) Analysis Provides a Clinical Context for the Surrogate Threshold Effect (STE): The ASBMR-SABRE Project Dana Bliuc Hospital admitted falls as a case-finding opportunity for individuals at high fracture risk Mike Lin Multimorbidity Double Burden: Elevated Refracture Risk despite High Mortality following Fractures Junko Tamaki Evaluation of the impact of the antiresorptive therapy after denosumab discontinuation on vertebral fracture risk in Japan: a nationwide study Sharon Chou MD The Interrelationship of Supplemental Vitamin D and Vitamin K Status on Bone Density and Structure: Results from VITamin D and OmegA-3 TriaL (VITAL)
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Oral Presentations: Regeneration and Fracture Healing
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Open to view video. Gurpreet Baht PhD, Mimi Sammarco PhD, Shuwan Liu, Maria Ethel Ridhima Seth BDS Gurpreet Baht PhD Neutralizing Hepatic Apolipoprotein E Enhances Aged Bone Fracture Healing Mimi Sammarco PhD TrkA+ sensory nerve signaling is required to promote digit regeneration Shuwan Liu Genomic Analysis of Sox9-Lineage Cells Reveals an Essential Role for c-FOS/AP-1 in Large-Scale Bone Regeneration Maria Ethel Transcriptomic and epigenetic regulation of Skeletal stem/progenitor cells during bone regeneration Ridhima Seth BDS, DMSc Ctsk+ Dental Cells Contribute to the function of PTH1r signaling in Tooth Eruption and Root Formation
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Oral Presentations: Rare Bone Diseases
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Open to view video. Steven Ing MD, MSCE, Roger Zebaze MD, Winnie Liu, Alison Boyce MD, Rodis Paparodis MD, FNLA Steven Ing MD, MSCE Effectiveness of Burosumab Versus Oral Phosphate and Active Vitamin D in Adults With X-Linked Hypophosphatemia (XLH) in a Real-World Setting: A 3-Year Follow-up of the XLH Disease Monitoring Program Roger Zebaze MD Disorganization of Bone Components in Metabolic and Genetic Bone Diseases like Hypophosphatasia: Novel Insights into the Pathogenesis and Patients Assessment. Winnie Liu Fracture rates in 6475 individuals with osteogenesis imperfecta stratified by age, sex and clinical severity. Alison Boyce MD A phase 2 trial of burosumab for treatment of fibroblast growth factor-23 mediated hypophosphatemia in children and adults with fibrous dysplasia Rodis Paparodis MD, FNLA Care Deficits in Hypoparathyroidism: Preliminary Data from a Greek Multicentre Registry Study on HypOPArathyroidism (The OPA study).
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Oral Presentations: Osteoclast Regulation and Bone Remodeling
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Open to view video. Ming-Qi Yan Master, Ting Zheng, Heng Qiu Ph.D., Tao Yang, Hejing Zhang Ming-Qi Yan Master Runx1-Mediated Transcriptional Regulation of Osteoclast Heterogeneity in Myeloid Cell Differentiation and Bone Homeostasis Ting Zheng 2-O-Sulfated Heparan Sulfate is a novel regulator selectively aggravating inflammatory osteoclastogenesis and arthritic bone erosion Heng Qiu Ph.D. Heme metabolism mediates RANKL-induced osteoclastogenesis via mitochondrial oxidative phosphorylation Tao Yang The deSUMOlyase SENP6 promotes osteoclastogenesis by silencing transposable elements and suppressing IFN/STAT1 signaling Hejing Zhang Osteoclast-Targeting Aptamer-Nanobait Platform Enhances Phagocytic Clearance of PD-L1+ Small Extracellular Vesicles for Combinatorial Therapy of Malignant Bone Metastasis and Neuropathic Pain
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Oral Presentations: Osteoblasts, Osteocytes and Bone Marrow Niche
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Open to view video. Siyuan Sun M.D., Qinwen Ge, Vivek Khanal Ph.D., Xiaoyu Xu Ph.D., Sarah Dallas Ph.D. Siyuan Sun M.D. Osteoblast-specific retinoic acid signaling inhibition causes skeletal and hematopoietic dysfunction in mice Qinwen Ge Phosphatase PPM1A promotes bone formation via regulating fatty acid metabolism mediated by TGF-β/Smad2 signaling in osteoblast Vivek Khanal Ph.D. Local, Not Global: Osteocyte-Derived LCN2 Drives Bone Remodeling via Wnt Pathway during homeostasis Xiaoyu Xu Ph.D. Lactation-induced Changes in Osteocyte Lacunae Are Spatially Heterogeneous and Persist After Weaning Sarah Dallas Ph.D. Insight into Collagen Assembly Dynamics by Live Cell Imaging in an Immortalized Osteogenic Cell Line Stably Expressing GFP-Collagen and Membrane Targeted TdTomato
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Oral Presentations: Obesity, Type 2 Diabetes and Bone
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Open to view video. Keity Okazaki MD, Elaine Yu MD, MMSC, Jawaad Chaudhry, Rimesh Pal MD, Hajin Jang MPH Keity Okazaki MD Bone Metabolism in Adolescents Undergoing Metabolic and Bariatric Surgery: Teen-LABS Cohort 15-years later Elaine Yu MD, MMSC Transition to Zoledronic acid after Denosumab in Adults receiving Bariatric Surgery: RCT Extension Study Jawaad Chaudhry Fracture Risk in Women Over 55 with Type 2 Diabetes Mellitus: A Comparative Analysis of GLP-1 Receptor Agonist Rimesh Pal MD Compromised Bone Quality and Reduced Bone Turnover in Newly Diagnosed Type 2 Diabetes Mellitus: Time to Screen for Skeletal Health at Initial Presentation? Hajin Jang MPH Associations of Obesity Phenotypes with Incident and Recurrent Falls in Older Adults: A Cross-Cohort Analysis
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Oral Presentations: New Tools for More Accurate Fracture Prediction
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Open to view video. Mattias Lorentzon MD, PhD, Sang Wouk Cho PhD, Muhammad Javaid PhD, Brian Clark PhD, Qing Wu MD, ScD Mattias Lorentzon MD, PhD A Novel Clinical Decision Support Tool for Accurate Hip Fracture Prediction Sang Wouk Cho PhD Spine age derived from DXA VFA images predicts incident fractures and mortality: the Manitoba Bone Mineral Density Registry Muhammad Javaid PhD Clinical and health economic benefits of AI-enabled vertebral fracture (VF) identification for Fracture Liaison Services (FLSs): the UK Adopt Study Brian Clark PhD Assessment of CBMT-Derived Ulna Flexural Rigidity Versus DXA-Derived Areal BMD for Discriminating Fragility Fractures in Postmenopausal Women Qing Wu MD, ScD Bayes-FRAX Improves Clinical Treatment Decisions for Older Women at Borderline FRAX Thresholds
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Oral Presentations: Molecular and Cellular Mechanisms in Rare Bone Conditions
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Open to view video. Roya Bagheri Ph.D., Valeria Guglielmi PhD, Jose Aguirre, Muthulakshmi Sellamani, Victoria DeMambro Roya Bagheri Ph.D. Investigating the COL1A1-Mutated Lung Matrix in Pulmonary Vulnerability of Osteogenesis Imperfecta Valeria Guglielmi PhD Investigating B cell function in hypophosphatasia Jose Aguirre An Increase in Necroptosis of Osteocytes and Oral Soft Tissue Cells Characterizes the Earliest Stage of Osteonecrosis of the Jaw Muthulakshmi Sellamani Mechanism of Cole Carpenter Syndrome Bone Pathology in a Mouse Model with Conditional Knockout of Sec24d Victoria DeMambro Improved VO2max, Muscle Function and Endurance in Adult HPP “PAKO” Mice Treated With Ilofotase Alfa
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Oral Presentations: Metabolic Bone Diseases
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Open to view video. Nina Hansen, Carlos A. Urrego, Sudipta Baroi, Jie Ren, Gerald Har PhD,Sharon Russo PhD Nina Hansen Insulin Signaling Determines Osteogenic Potential in Skeletal Stem Cells from Patients with Type 2 Diabetes Carlos A. Urrego Type 2 Diabetes Alters Bone Architecture and Compressive Stress in a Spatially Dependent Manner Sudipta Baroi Single cell profiling reveals transcriptional reprogramming of pre-osteoblasts, osteoblasts and osteocytes by diabetes and restoration by activation of the PTH1R/SIK axis Jie Ren Gerald Har PhD Accelerated osteocytic citrate production in chronic kidney disease is associated with protection of the kidney from further injury Sharon Russo PhD ZNF687 as a Modulator of Osteoclast Progenitor Fate and Paget’s Disease of Bone Pathogenesis
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Oral Presentations: Mechanobiology of Bone Modeling and Remodeling
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Open to view video. Taylor deVet MASc., Renae Duncan, Giuliana Fagre Guerriero, Christopher Panebianco PhD, Juan Hanel Taylor deVet MASc. Mechanical loading leads to short- and long-term adaptation in blood vessels and bone vessel porosity within the murine hindlimb Renae Duncan Role of Mitochondrial Genetics in the Response of Bone Marrow Stromal Cells to Mechanical Stimulation Giuliana Fagre Guerriero Decoding Wolff’s Law: Bone Remodeling in Individual Trabeculae under Mechanical Loading Christopher Panebianco PhD Maternal Exercise Rescues Fetal Akinesia-Impaired Joint and Bone Development Juan Hanel Age-Dependent Skeletal Degradation in BALB/c Mice Following 39 Days of Spaceflight
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Oral Presentations: Mechanisms of Skeletal Adaptation in Aging, Loading, and Disease
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Open to view video. Annemarie Lang PhD, David Maridas, Froilan Granero-Molto PhD, Gurcharan Kaur PhD, Leanne van der Merwe MBBS Annemarie Lang PhD Localized Erythropoietic Activation After Fracture Modulates Bone Marrow Oxygenation and Repair David Maridas Inhibiting Bone and Muscle Loss in Aged Mice by Targeting the Alk4 Pathway Froilan Granero-Molto PhD A Transcriptional Hub for Endochondral Ossification and Fracture Repair Gurcharan Kaur PhD APOE4 Exerts Sexually Dimorphic Effects on Bone Quality in a Mouse Model of Neurodegeneration Leanne van der Merwe MBBS Osteocyte-conditional knockout of Bmal1 results in decreased bone formation response to in vivo tibial loading in mice
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Oral Presentations: John Carstens - Osteoporosis Treatment
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Open to view video. Lauren Lynch, Koji Ishikawa, Kristyn Hare, Rachel Wagman, Mike Lin Lauren Lynch Romosozumab is associated with large BMD increases in premenopausal idiopathic osteoporosis Koji Ishikawa Twice Weekly Teriparatide Failed to Maintain the Gains in Bone Strength Induced by Romosozumab in Japanese Women With Postmenopausal Osteoporosis in Clinical Practice Kristyn Hare Revisiting the ADFR Concept: Clinical Use of Cyclic Romosozumab Rachel Wagman MD Effects of EB613 Tablets [Oral PTH(1-34)] on Trabecular and Cortical Bone Using 3D-DXA: Results from Phase 2 Study Mike Lin Bisphosphonates or Denosumab after Fracture? Real-World Evidence from a Target Trial Emulation in Multimorbid Adults
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Oral Presentations: Insights Driving Change in Bone Health Management
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Open to view video. Didier Hans, Angela Cheung MD, PhD, Jovan Milosavljevic, Guido Cavati MD, Nick Tran Didier Hans Comparative Effects of Bone Area from DXA on TBS and Bone Mineral Density: The Manitoba BMD Registry Angela Cheung MD, PhD Prevalence of Variants in the ALPL Gene in Patients with Atypical Femoral Fractures in the Ontario AFF Cohort Study Jovan Milosavljevic Denosumab versus Bisphosphonates for Inpatient Hypercalcemia of Malignancy: A Real-World Comparative Analysis Guido Cavati MD Low serum phosphate levels and fragility fracture risk: a population based prospective study Nick Tran Reversible Impact of Cigarette Smoking on Fragility Fractures
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Oral Presentations: Inflammation, Immunity, and Bone Regulation
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Open to view video. Ernesto Canalis MD, Yiran Song, Xiaohao Wu, Rachelle Johnson PhD, Zhiming Jin M.S. Ernesto Canalis MD Activation of NOTCH3 Precludes Corticalization and Skeletal Integrity Yiran Song Gα13 Functions as a Negative Endogenous Regulator of Macrophage-Mediated Inflammation and Bone Destruction in Rheumatoid Arthritis via the Gα13–TLR–NF-κB Signaling Pathway Xiaohao Wu Preclinical Expansion of Autoreactive Naive B cells Drives RA onset in ACPA+ individuals Rachelle Johnson PhD Immune Checkpoint Blockade of PD-L1 but not PD-1 Spares Bone Microarchitecture and Promotes Clearance of Bone Metastatic Breast Cancer Cells Zhiming Jin M.S. Macrophage dysfunction enhances bone marrow stromal cell efferocytosis and accelerates myeloid skewing
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Oral Presentations: Greg Mundy Session on Cancer and Bone - Cancer-Bone Interactions and Metastases
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Open to view video. Karina Geurtzen PhD, Kunjan Khanna PhD, Jennifer Zarrer, Aric Anloague, Jeremy Kane Karina Geurtzen PhD Breast cancer cells rely on mitochondrial respiration to support bioenergetics and de novo lipogenesis to form bone metastases Kunjan Khanna PhD Fibroblast-derived Dkk1 contributes to bone loss in physiological conditions and during breast cancer progression Jennifer Zarrer Osteoprogenitor-derived Bone Metastases-Associated Fibroblasts (BMAFs) support Breast Cancer Bone Metastases by Remodeling the Extracellular Matrix Aric Anloague Autocrine Osteocyte FGF23-Klotho Signaling Drives Bone Pathology in Multiple Myeloma. Jeremy Kane Abaloparatide increases bone mass but depletes bone marrow T cells and does not improve tumor clearance in mice treated with immune checkpoint blockade
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Oral Presentations: Fueling Strength: Gut Microbiome, Food Intake and Exercise Synergy
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Open to view video. Marina Vilar, Geraldi PhD, Didier Hans, Andrea Trombetti, Prof., Dr Belinda Beck, Shivani Sahni PhD Marina Vilar Geraldi PhD Gut Microbiota Associations with Incident Fractures, Bone Density, and Physical Function in Older Swedish Women: Findings from the SUPERB Cohort Didier Hans Is Trabecular Bone Score Associated with Appendicular Lean Mass? Andrea Trombetti Prof. Dr Effect of Dalcroze Eurhythmics Exercise on Muscle, Physical and Cognitive Function, and Falls in Sarcopenic Older Adults: The SARCARE Randomized Controlled Trial Belinda Beck Factors Influencing the Dose Response of BMD to Targeted Exercise Therapy: an Ongoing Real World Experiment Shivani Sahni PhD Dietary Protein and Amino Acids are Associated with Higher Deuterated Creatine (D3Cr) Muscle Mass in Older Women: the Framingham Offspring Study
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Oral Presentations: Cartilage in Crisis - Signaling Information and Intervention
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Open to view video. Fangzhou Bian, Guiwu Huang M.D., Rui Hua, Chiaki Arai, Kosuke Ebina M.D., Ph.D. Fangzhou Bian A Cartilage-Enriched G Protein-Coupled Receptor Maintains Articular Cartilage Homeostasis via Promoting Gs Signaling in Mice Guiwu Huang M.D. Cytosolic Phospholipase A2 as a Therapeutic Target for Osteoarthritis Rui Hua Targeting Synovial Connexin 43 Channels Attenuates Inflammation and Pain in Osteoarthritis Chiaki Arai A Condylar Cartilage-specific Mechanoprotective Role of Runx2 via MMP13 Suppression Kosuke Ebina M.D., Ph.D. Receptor activator of nuclear factor-kappa B ligand-derived microglia healing peptide 1-AcN inhibits osteoarthritis progression in mice
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Oral Presentations: Bone Marrow Cells and the Microenvironment
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Open to view video. Xiyu Ge PhD, Humberto Reyes-Pardo, Adam Tyrlik B.S., Ziang Xie, PhD, Jane Joy, Thomas PhD Xiyu Ge PhD Expansion of Adipo-CAR Cells Is Associated with Skeletal And Hematopoietic Phenotypes in Pth1r-OsxKO Mice Humberto Reyes-Pardo Osteo-CAR cells are self-renewing osteoblast progenitors in remodeling bone that do not decline with age Adam Tyrlik B.S. Conserved disruption of human bone marrow stromal cells’ transcriptional and functional heterogeneity in Myelodysplastic Syndromes Ziang Xie PhD Dysregulation of DDAH1/ADMA impairs endothelial cell mitophagy and alters the differentiation fate of BMSCs by modulating exosomal miRNA-19b-2-5p delivery Jane Joy Thomas PhD Intact FGF23 produced by erythroid cells is a paracrine inhibitor of erythropoiesis
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Oral Presentations: Bone Health in Special Populations
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Open to view video. Ludovica Santi, Sisir Kumar Barik Ph.D.,Giulia Battafarano PhD, Ling Wang, Catrina Silveira DVM, MS, DACVS-SA Ludovica Santi Skeletal Disease and Cross-correction Mechanisms after ex-vivo Gene Therapy in Mucopolysaccharidosis type I-Hurler Sisir Kumar Barik Ph.D. PDGF-BB Overexpression Prevents Sex-Specific Glucocorticoid-Induced Bone and Vascular Loss via the CXCL12-PDGF-BB Axis Giulia Battafarano PhD Analysis of the effects of Pepstatin A/Cysteamine Combined Treatment on Bone Remodeling Activity of Cystinotic Mice Ling Wang FGF21 Overexpression Exacerbates Bone Loss and Increases Bone Marrow Adiposity in a Mouse Model of Duchenne Muscular Dystrophy Catrina Silveira DVM, MS, DACVS-SA Secondary but not primary bone healing is impaired in the Dp16 mouse model of Down syndrome
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Oral Presentations: Bone Healing and Energy Metabolism
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Open to view video. Sofia Moverare-Skrtic PhD, Lutian Yao, Jingwen Yang, Joe Kodama, Kai Chen M.D., Ph.D. Sofia Moverare-Skrtic PhD Identification of Ephrin-A1–EphA2 Signalling as a Potential Target for Fracture Prevention Lutian Yao Integrating spatial and single-cell transcriptomics to characterize mouse long bone fracture healing process Jingwen Yang BMP signaling interacts with environmental stress causing craniofacial defects via metabolomic-epigenetic cascade Joe Kodama Uncovering lipid metabolism in the growth plate Kai Chen M.D., Ph.D. Single-Cell Spatial Mapping of Glucose Utilisation in Bone
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Oral Presentations: Bone Aging, Senescence, and Systemic Signals
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Open to view video. Ryan Neilson MS, David Achudhan Ph.D., M.S., Surendra Kumar Ph.D, Atefe Ali, Moradi MD, Yunxin Chen Ryan Neilson MS Osteoclast beta-1 adrenergic receptor contributes to age-related trabecular bone loss in female mice David Achudhan Ph.D., M.S. Genetic and Pharmacological Targeting of Acute Senescence-Related Molecular Changes to Mitigate Chronic Bone Loss Surendra Kumar Ph.D Senescent Bone Marrow Adipocytes Drive Bone Loss through SAP/PTX2-Mediated Amyloidosis Atefe Ali Moradi MD The Soluble Isoform of Colony Stimulating Factor 1 Modulates the Anabolic Response to PTH in the Spine of Female Mice Yunxin Chen Ageing Affects Mechanosensitivity of Human Osteocytes
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Oral Presentations: Biomechanics and Bone Quality
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Open to view video. Isabel Mauricio Amado PhD, Natasha Hunt MS, Emily Berestesky B.S., Melia Matthews, Taraneh Rezaee Ph.D. Isabel Mauricio Amado PhD Mitochondrial Mechanisms of Age-related Decline in Bone Quality and Osteocyte Function Natasha Hunt MS Modifications to the gut microbiome alter matrix proteomics and fracture toughness at the cellular scale Emily Berestesky B.S. Effects of Type 2 Diabetes on Trabecular Bone of Cadaveric Proximal Femurs Melia Matthews Local Treatment with Cholesterol-Depleting MβCD Increases Osteocyte Mechanosensitivity in vivo Taraneh Rezaee Ph.D. Adverse outcomes with long-term alendronate suppression of remodeling in fatigued rat ulnae: An in vivo model for atypical fractures?
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Meet-the-Professor: Menopause and Musculoskeletal Health - A Workplace Dialogue
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Open to view video. Laura Fejerman MSc., PhD Menopause and Musculoskeletal Health - A Workplace Dialogue
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Late-Breaking Oral Presentations: Translational Science
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Open to view video. Hitoshi Tanigawa, Gabriel Pagnotti PhD, Sung-Hee Yoon, Delphine Farlay PhD, Huy Nguyen Hitoshi Tanigawa A modified type II activin receptor ligand trap as a novel treatment for Osteogenesis Imperfecta Gabriel Pagnotti PhD Low intensity vibration prevents age-related vertebral bone loss and preserves muscle strength in DP16 Down Syndrome mice Sung-Hee Yoon Oral Salt Inducible Kinase inhibitor treatment increases calcium and bone remodeling in a mouse model of hypoparathyroidism Delphine Farlay PhD The Role of Bone Marrow Adipose Tissue in Bone Metabolism in Type 2 Diabetes Mellitus: The DIABONE Study Huy Nguyen Accurate Identification of High-risk Individuals for Imminent Subsequent Fractures: A Deep Learning Approach using Administrative Data
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Late-Breaking Oral Presentations: Clinical Science II
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Open to view video. Eugene McCloskey MD, FRCPI, Douglas Bauer, Elena Gonzalez Rodriguez MD, PhD, Sanaa Badour, Mason Shaffer Eugene McCloskey MD, FRCPI Impact of FRAXplus adjustments versus FRAX on Fracture Risk Classification in the Swiss Osteoporosis Registry Douglas Bauer Relative Utility of 2024 ASBMR Criteria for the Radiographic Diagnosis of Atypical Femoral Fracture (AFF) Elena Gonzalez Rodriguez MD, PhD Determining Optimal CrossLaps Thresholds for the Prevention of Bone Loss at One and Two Years Following Denosumab Discontinuation: The ReoLaus Study Sanaa Badour Comparative Effectiveness and Safety of Continuing Bisphosphonates Beyond 3 Years: A Real-World Cohort Study Mason Shaffer Associations Between Hip Muscle Properties and Bone Mineral Density in Older Adults of the Study of Muscle, Mobility and Aging (SOMMA): A Computed Tomography (CT) Ancillary Study
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Late-Breaking Oral Presentations: Clinical Science I
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Open to view video. Ciara McDonnell MD, Stuart Ralston MB ChB, MD, FRCP, FMedSci, FFPM (Hon) FRSE, Stuart Warden Ph.D., Elizabeth Orhadje, Spencer Hills Ciara McDonnell MD Once-Weekly Lonapegsomatropin (TransCon hGH) Added to Once-Weekly Navepegritide (TransCon CNP) in Children with Achondroplasia: 26-Week Results from the Phase 2 COACH Trial Stuart Ralston MB ChB, MD, FRCP, FMedSci, FFPM (Hon) FRSE Initial results of the TOPAZ study: A randomised trial of teriparatide and zoledronic acid compared with standard care in adults with osteogenesis imperfecta Stuart Warden Ph.D. HR-pQCT Characterization of Autosomal Dominant Osteopetrosis Reveals Fractures Occur in the “Strongest” Bones According to Failure Load Elizabeth Orhadje Polygenic risk score analysis reveals that women with pregnancy-associated osteoporosis have an over-abundance of alleles associated with low spine BMD compared to controls Spencer Hills Longitudinal HRpQCT Imaging Demonstrates Rapid Periosteal Bone Loss in a Cohort of Older Men
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Late-Breaking Oral Presentations: Basic Science
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Open to view video. Rui Peng, Hang Lin PhD, Kalpana Patel PhD, Shreya Venkatesh, Cui Zhang Rui Peng PDHA1 Deacetylation by SIRT3 Drives Energetic Metabolism Switching to Enhance Osteoclast Activity and Bone Resoprtion in Postmenopausal Osteoporosis Hang Lin PhD Long-term evaluation of human iPSC-derived cartilage for repairing chondral defects Kalpana Patel PhD Identification of Bmp and Activin Membrane-Bound Inhibitor (Bambi) as a Novel PTH Target Gene in Osteocytes, Required for Sclerostin Repression and Skeletal Homeostasis Shreya Venkatesh Serpin E1 Underpins the Tumor-Osteocyte Response to Fluid Shear and Irradiation Cui Zhang Genome-wide CRISPR/Cas9 screening identified KMT2F as a key epigenetic regulator of skeletal stem cell senescence and whole-body aging
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Joint ASBMR-IOF Session: Improving Bone Health Outcomes Worldwide: Equity, Coordination, and Evidence-Based Interventions
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Open to view video. Nicholas Harvey MA, MB, BChir, PhD, Nicola Napoli MD, PhD, Maria Diehl MD Nicholas Harvey MA, MB, BChir, PhD Novel Approaches for Equitable Bone Health Management Worldwide Nicola Napoli MD, PhD Improving Outcomes after Fragility Fractures: Introduction and Current Global Status of these Strategies Maria Diehl MD Evidence of the Impact of Inpatient Zoledronic Acid in Mortality and Refracture Reduction
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International Meetup: Exploring Global Research in Bone Science - Fostering New Connections with the Central and South American Regions
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Open to view video. Pamela Trejo MD, Vanesa Longobardi MD, Jose Mansur MD, Roberto Enrique Lopez Cervantes, MD, Mariana Kiomy Osako, PhD, Pierrick GJ Fournier Pamela Trejo MD Description of Regional Bone societies and Representation in Journal’s Editorial Boards and International Societies Vanesa Longobardi MD Description of Regional Bone Societies and Representation in Journal’s Editorial Boards and International Societies Jose Mansur MD Bringing Local Science to the Global Stage Roberto Enrique Lopez Cervantes, MD Evidence-Based Joint Statement Position of Bone Health Optimization in the arthroplasty candidate, from 7 national societies Mariana Kiomy Osako, PhD RANKL enhances muscle strength and endurance in mice Pierrick GJ Fournier Turning cold breast cancer bone metastases hot using 5-fluorouracil to reduce MDSC and increase T cell infiltration
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International Meetup: Exploring Global Research in Bone Science - Fostering New Connections with the Asian Pacific Regions
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Open to view video. Yumie Rhee MD, PhD, Yuuki Imai PhD, Natalie Sims PhD, Natthinee Charatcharoenwitthaya MD, Xin Yang, Yoshitomo Hoshino, MD, PhD, Nick Tran, Beom-Jun Kim, MD, PhD Yumie Rhee MD, PhD KSBMR Yuuki Imai PhD JSBMR Natalie Sims PhD ANZBMS Natthinee Charatcharoenwitthaya MD AFOS AptGEN: Rapid Discovery of AI-Generated Aptamers Targeting CTGF CT-domain for DMD Fibrosis Xin Yang Identification of a Novel Mechanism of Acquired Osteomalacia Associated with Anti-PHEX Autoantibodies: Autoimmune Osteomalacia Yoshitomo Hoshino, MD, PhD “Skeletal Age” for Cumulative Impact of Cigarette Smoking on Post-fracture Mortality Nick Tran ALDH1A1 as a Potential Therapeutic Target for Postmenopausal Sarcopenia: From Proteomic Discovery to Translational Validation Beom-Jun Kim, MD, PhD,
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International Meetup: Exploring Global Research in Bone Science - Fostering New Connections with the Africa, Middle East and India Regions
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Open to view video. Flavia Matovu DDS, PhD, Ghada Fuleihan FRCP, MD, MPH, Marlene Chakhtoura MD, MSc, Nitin Kapoor MD, PhD, Rimesh Pal MD Nitin Kapoor MD, PhD India Region Rimesh Pal MD India Region Flavia Matovu DDS, PhD Africa Region Ghada Fuleihan FRCP, MD, MPH Middle East Region Marlene Chakhtoura MD, MSc Middle East Region Panel Discussion
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Highlights of the ASBMR 2025 Annual Meeting
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Open to view video. Benjamin Leder MD Clinical Highlights Lorenz Hofbauer MD Translational Highlights Natalie Sims PhD Basic Highlights
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Esteemed Awards Presentations and Louis V. Avioli Lecture
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Open to view video. Jose Luis Millan PhD Louis V. Avioli Lecture: Hypophosphatasia – Looking beyond the Skeleton
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Early Career Spotlight Rapid Fire
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Open to view video. Allison Abney, Lutian Yao, Valentina Daponte PhD, Alexander Dash MD, MSCR, Tonio Lipkow, Flavia Matovu DDS, PhD, Valeria Iannello, Xiaohui Tao Allison Abney Duchenne Muscular Dystrophy leads to Concurrent Muscle and Bone Disease with a Loss of Osteoblastic Bone Cell Populations Lutian Yao High-resolution spatial mapping of femoral periosteum in young and aged mice Valentina Daponte PhD Osteoclast-Derived Wnt5a Promotes Bone Anabolism by Influencing Osteoblast Function Alexander Dash MD, MSCR Bone Phenotype by HR-pQCT Predicts Skeletal Complications After Spinal Fusion Surgery Tonio Lipkow Sex-Specific Microstructural Responses to Long-Term Denosumab: Evidence of Endosteal Apposition in a 6-Year HR-pQCT Cohort Study Flavia Matovu DDS, PhD Recovery in Bone Mineral Density Following Recent Repeat Pregnancy and Extended Breastfeeding among African Women With and Without HIV Valeria Iannello Advancing gene therapy through ex vivo HSC expansion for effective treatment of Autosomal Recessive Osteopetrosis Xiaohui Tao Targeting Sclerostin Loop3 could Enhance Serum Phosphorus Levels and Promoting Bone Formation in Hyp Mice
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Committee-Sponsored Symposium: Improving Science Literacy through Efficient Communication with the Public
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Open to view video. Christopher Hernandez PhD, Michael Hadjiargyrou PhD, Rachel Menegaz PhD Christopher Hernandez PhD Communicating Science from the Academia Michael Hadjiargyrou PhD Role of Scientific Societies on Communicating Science to the Public Rachel Menegaz PhD How to Accurately and Effectively Communicate with Diverse Audiences
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Clinical Symposium: Task Forces and Work Groups Updates
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Open to view video. Adi Cohen MD, MS, Matthew Drake MD, PhD, Angela Cheung MD, PhD, Peter Ebeling MBBS, MD, Dennis Black PhD, Mary Bouxsein PhD, Benjamin Leder MD, Elaine Yu MD, MMSC Adi Cohen MD, MS ASBMR Task Force on Discontinuation of Denosumab Therapy for Osteoporosis Matthew Drake MD, PhD ASBMR Task Force on Discontinuation of Denosumab Therapy for Osteoporosis Angela Cheung MD, PhD ASBMR Task Force Report on Atypical Femoral Fractures Peter Ebeling MBBS, MD ASBMR Task Force Report on Atypical Subtrochanteric and Diaphyseal Femoral Fractures Dennis Black PhD SABRE Update Mary Bouxsein PhD SABRE Update Benjamin Leder MD Harmonization of Osteoporosis Guidelines in North America Elaine Yu MD, MMSC Harmonization of Osteoporosis Guidelines in North America
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Clinical Symposium: Osteonecrosis of the Jaw
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Open to view video. Tara Aghaloo DDS, MD, PhD, John Grbic DMD, MS, MMSC, Peter Ebeling MBBS, MD Tara Aghaloo DDS, MD, PhD Update in Physio Pathogenesis and Diagnosis John Grbic DMD, MS, MMSC Epidemiology & Dental Management of Osteonecrosis of the Jaw Peter Ebeling MBBS, MD Medical Treatment and Prevention Strategies
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Clinical Symposium: Emerging Therapies for Rare Bone Diseases
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Open to view video. Michael Mannstadt MD, Nobuaki Ito MD, PhD, Elena Gonzalez Rodriguez MD, PhD Michael Mannstadt MD PTH Therapy for Hypoparathyroidism: Why Not for All? Nobuaki Ito MD, PhD Acquired Osteomalacia Associated with Autoantibodies against PHEX E lena Gonzalez Rodriguez MD, PhD Use the Rare to Understand the Common
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Clinical Symposium: Challenge the Experts - Interactive Real-Life Cases
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Open to view video. Elaine Yu MD, MMSC, Felicia Cosman MD, Sabashini Ramchand MD Elaine Yu MD, MMSC Challenge the Experts Felicia Cosman MD Challenge the Experts Sabashini Ramchand MD Challenge the Experts
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Career Development: Translating Science - Mastering the Art of Lay Summaries
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Open to view video. Deborah Veis MD, PhD Translating Science: Mastering the Art of Lay Summaries
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Career Development: Securing the Global Pipeline of Bone Experts
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Open to view video. Eva Liu MD, John Bilezikian MD, PhD, Naga Yalla MD, Aliya Khan MD, Ghada Fuleihan FRCP, MD, MPH, Jad Sfeir MD, MSc, Ghada Fuleihan FRCP, MD, MPH Eva Liu MD Shortfalls in the Pipeline of Physicians and Educator Experts in Metabolic Bone Disease: Augmenting Global Capacity John Bilezikian MD, PhD Bone training at Columbia University and at the Endocrine Fellows Foundation at ASBMR Naga Yalla MD Existing Prototypes of Bone Fellowship Training Programs: Washington University in St. Louis, USA Aliya Khan MD Existing Prototypes of Bone Fellowship Training Programs: McMaster University, Canada Ghada Fuleihan FRCP, MD, MPH Existing Prototypes of Bone Fellowship Training Programs: American University of Beirut, Lebanon Jad Sfeir MD, MSc Existing Prototypes of Bone Fellowship Training Programs: Mayo Clinic, USA Ghada Fuleihan FRCP, MD, MPH A Blueprint for a Desired Fellowship Training Program in Bone and Mineral Diseases
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Career Development: Meet the NIH
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Open to view video. Kristy Nicks PhD
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Career Development: How to Train a Scientist in the Musculoskeletal Health Field
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Open to view video. Lynda Bonewald, Danielle Benoit, Rocky Tuan PhD Lynda Bonewald How to Create an Integrative Program for Musculoskeletal Health Danielle Benoit Experience from T32 Programs Designed to Train New Investigators (Graduate Students, Postdocs) in the Field. Rocky Tuan PhD International Collaborations for Education and Experience
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Basic/Translational Symposium: Pathophysiological Interplay of Bone with Other Tissues
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Open to view video. Brenda Smith PhD, Yusuke Shiozawa MD, PhD, Caroline Taylor, Eduardo Duque, Hannah Herzog Brenda Smith PhD Title TBD Yusuke Shiozawa MD, PhD The crosstalk between gut leakiness and cancer-induced bone pain Caroline Taylor CTHRC1 Regulates the Regenerative Response via Modulation of Cellular Metabolism and Inflammation Eduardo Duque Kidney HNF4A regulates phosphate reabsorption and bone and mineral metabolism during CKD progression Hannah Herzog Ablation of the Gut Microbiome Uncovers a Metabolic-Immune Axis in Fibrodysplasia Ossificans Progressiva
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Basic/Translational Symposium: Impacts of Sexual Dimorphism on the Musculoskeletal System
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Open to view video. Laura Tosi MD, Tamara Alliston PhD, Simon Tang PhD Laura Tosi MD Reporting Sex Differences in Musculoskeletal Conditions Tamara Alliston PhD Sexually dimorphic Osteocytic Control of Bone Quality in Health, Aging, and Disease Simon Tang PhD Sex-Specific Divergences in Immune Cells Response during the Intervertebral Disc Degeneration
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Basic/Translational Symposium: Diverse Cellular Roots for Repair, Regeneration and Rejuvenation
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Open to view video. Noriaki Ono DDS, PhD, Fanxin Long PhD, Paola Divieti Pajevic MD, PhD Noriaki Ono DDS, PhD Bone Marrow Endosteal Space: A Youthful Source of Bone-making Cells Fanxin Long PhD Bone Regeneration in Homeostasis and Repair: A Tale of Two Progenitors Paola Divieti Pajevic MD, PhD Title TBD
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Basic/Translational Symposium: Crying Wolff - 130 Years of Wolff’s Law
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Open to view video. X. Edward Guo PhD, Yingzi Yang PhD, Mary Bouxsein PhD, Karen Troy PhD X. Edward Guo PhD Introduction Yingzi Yang PhD Molecular and Cellular Sensors of Mechanical Forces in Skeletal Development and Diseases Mary Bouxsein PhD Use It or Lose It: Skeletal Effects of Unloading and Spaceflight Karen Troy PhD Human Bone Adaptation and Creation through Mechanosensation - Translation!
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Basic/Translational Symposium: Cancer-Associated Bone Disease
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Open to view video. Hiroshi Takayanagi MD, PhD, Dorothy Sipkins MD, PhD, Robert Satcher MD, PhD Hiroshi Takayanagi MD, PhD Bone-Specific Cancer Resistance and Vulnerability Dorothy Sipkins MD, PhD Bone Metastases Take an Unexpected Path to the CNS Robert Satcher MD, PhD The TGFBI 'Vicious Cycle': Does it Explain Treatment-Resistance for Bone Metastasis?
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Basic/Translational Symposium: ASBMR/ISBM Joint Session - Cutting Edge Tools for Studying Skeletons
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Open to view video. Anja Hauser PhD, Karl Lewis PhD, Eric Orwoll MD Anja Hauser PhD Using advanced optical microscopy to uncover mechanisms of how immune cells drive bone regeneration Karl Lewis PhD Intravital Imaging Techniques and Mechanotransduction in Bone Eric Orwoll MD AGA2115, a Bispecific Antibody Neutralizing DKK1 and Sclerostin, Increased Bone Formation, Decreased Bone Resorption, and Led to Significant BMD Gains in a First-in-Human, Single- and Multiple-dose, Placebo-Controlled Randomized Study
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ASBMR/ORS/NASS Joint Session: Bone Health and Spine Surgery - A Multidisciplinary Approach to Optimizing Outcomes, Addressing Gaps and Advancing Solutions
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Open to view video. Hicham Drissi PhD, Nilsson Holguin PhD, Augusto Hsia Jr. MD CCD ASBMR/ORS/NASS Joint Session: Bone Health and Spine Surgery - A Multidisciplinary Approach to Optimizing Outcomes, Addressing Gaps and Advancing Solutions
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ASBMR/IFMRS Joint Session: Integration of Large Data Sets and Systems Biology for Musculoskeletal Diseases
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Open to view video. Ronald Y. Kwon, PhD, Charles Farber, PhD Skeletal Genophenomics in Zebrafish: Rapid Imaging and Gene Discovery Ronald Y. Kwon, PhD, University of Washington, USA Charles Farber PhD Systems Approaches to Investigate the Molecular Basis of Bone Fragility
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ASBMR/ECTS Clinical Debate: All Individuals over Age 50 with a Recent Fracture, Including Traumatic Fractures, Should be Assessed for Treatment for Osteoporosis.
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Open to view video. Steven Cummings MD, Muhammad Javaid PhD, Steven Cummings MD, Muhammad Javaid PhD Steven Cummings MD ASBMR - For the Motion Muhammad Javaid PhD ECTS - Against the Motion Steven Cummings MD ASBMR - Rebuttal Muhammad Javaid PhD ECTS - Rebuttal
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ASBMR Pre-Meeting Session 4: Future Therapeutic, Analytical and Diagnostic Tools
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Open to view video. Julia Charles MD, PhD, Edward Schwarz PhD, Wenyu Fu Julia Charles MD, PhD Role of RANKL/osteoclasts in Fibrous Dysplasia Edward Schwarz PhD Translation opportunities in osteomyelitis Wenyu Fu BIG2-mediated dual inhibition of TNF? and IL-1? signaling ameliorates osteoarthritis in mouse and mynomolgus macaque models
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ASBMR Pre-Meeting Session 3: Pathogenesis of Cancer and Age-associated Disorders
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Open to view video. Roberta Faccio PhD, Leah Cook MS, PhD, Lorenz Hofbauer MD, Pallavi Budgude Roberta Faccio PhD DKK1 creates a tumor-supporting environment through the suppression of NK cells during breast cancer progression Leah Cook MS, PhD Neutrophil anti-tumor responses against bone metastatic prostate cancer: mechanisms and therapeutic opportunities Lorenz Hofbauer MD Clonal hematopoiesis and its impact on the aging osteo-hematopoietic (CHIP, MDS and its implication on bone health) Pallavi Budgude An inflammatory osteoblast niche marks blood cancer progression and promotes malignant stem cell stemness and expansion through serum amyloid A1
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ASBMR Pre-Meeting Session 2: Musculoskeletal Impact of Immune Cells
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Open to view video. Laura Calvi MD, Nathan Pavlos Ph.D., Jae Hyuck Shim, Ashish Tripathi Laura Calvi MD Skeletal and Hematopoietic Consequences of Efferocytosis of Apoptotic Cells in the Bone Marrow Nathan Pavlos Ph.D. Role of a tubular lysosomal network in osteoclast function Jae Hyuck Shim Inhibition of Schnurri 3 in osteoblasts suppresses systemic and articular bone loss in models of inflammatory arthritis Ashish Tripathi Gut microbiota drive Immune Reconstitution Bone Loss during Antiretroviral Therapy against HIV, through Antigen-Dependent T Cell activation
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ASBMR Pre-Meeting Session 1: Reciprocal Interactions of Skeletal and Immune Cells
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Open to view video. Laura Calvi MD, Natalie Sims PhD, Baohong Zhao DMD, PhD, Lena Batoon PhD Laura Calvi MD Introduction & Overview Natalie Sims PhD Neutrophil progenitors: protecting the skeleton from their home in the marrow Baohong Zhao DMD, PhD Reciprocal suppression between TGFβ signaling and TNF stimulation finetunes the macrophage inflammatory response and osteoclastogenesis Lena Batoon PhD Macrophage efferocytosis impacts the skeleton
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