ASBMR 2026 Annual Meeting Recordings
Recorded On: 10/08/2026
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ASBMR 2026 Annual Meeting Session Recordings (October 9-12, 2026)
John B. Hynes Veterans Memorial Convention Center, Boston, Massachusetts.
To access the recordings from the ASBMR 2026 Annual Meeting, please click the Contents tab. If you registered for the ASBMR Annual Meeting, you DO NOT need to purchase recordings - you should have received an email with instructions to access the recordings. Please contact [email protected] with any questions!
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ASBMR 2026 Pre-Meetings (Bone Quality and Rare Bone) Thursday 10/8/2026
ASBMR/Bone Quality Pre-Meeting Session 1: Unmet Clinical Needs to Diagnose and Treat Bone Quality
Open to view video.
Open to view video.
Presentations: Introduction; Revealing Hidden Fragility: The Microstructural and Material Determinants of Bone Quality in Individuals with Type 2 Diabetes (Eve Donnelly, PhD); How Does Aging Affect Bone Quality? A Geroscience Approach (Gustavo Duque, PhD, MD); Metabolic Bone Disease: From Rare to Common (Peter R. Ebeling, MBBS, MD); PM-095: Quality of Bone Matrix and Toughness Decline with Age in Female C57BL/6N Mice (Emily Daria Berestesky, PhD Student)
ASBMR/Bone Quality Pre-Meeting Session 2: Mechanometabolic Control of Bone Quality
Open to view video.
Open to view video.
Presentations:
How the Osteocyte Network Changes as Women Age (Natalie A. Sims, PhD)
Osteocytic Calibration of Bone ECM Material Properties (Tamara N. Alliston, PhD)
Composition and Nanomechanical Properties of Bone Tissues Formed through Modeling- and Remodeling-Based Bone Formation (Yongqiang Vincent Jin, PhD student)
Citrate Transport Regulates Calcium Distribution, Hydroxyapatite Maturation, and Osteocyte Lacunar Architecture (Naomi Dirckx, PhD)
ASBMR/Bone Quality Pre-Meeting Session 3: Emerging Technologies in Bone Quality Assessment
Open to view video.
Open to view video.
Presentations:
Cortical Bone Mechanics Technology: A Biomechanical Approach to Assessing Bone Quality (Brian Clark, PhD)
Evaluating Bone Strength and Fragility Using the Osteoprobe (Simon Yue-Cheong Tang, PhD, MSCI)
3D Quantitative Ultrasound Imaging of Bone (3D QUSIB) (Kay Raum, PhD)
Serum Biomarkers - A Biochemical Window into Bone Quality and Fracture (Deepak Vashishth, PhD)
ASBMR/Bone Quality Pre-Meeting Session 4 - Bone Quality Diagnostics
Open to view video.
Open to view video.
Presentations:
New Ways of Assessing Osteocyte Characteristics in Health and Disease: Markus A. Hartmann, PhD
Genetic Architecture of Bone Quality: Charles R. Farber, PhD
Pore Water and Bound Water as Predictors of Bone Fragility: Jeffry Nyman, PhD
Long-standing bone microdamage is not repaired during a bisphosphonate drug holiday: Abigail A Coffman, PhD
ASBMR/Bone Quality Pre-Meeting Session 5: Novel Bone Quality Indicators & Therapeutics
Open to view video.
Open to view video.
Presentations: The Gut Microbiome and Age-Related Impairment of Bone Quality (Christopher J. Hernandez, PhD)
Is There an Ideal Drug or Drug Target to Improve Bone Quality? (Serge Livio Ferrari, MD)
Counting Molecules: Ultrasensitive Detection and the Next Generation of Biomarker Panels (Arek V. Melkonian, MD, PhD)
ASBMR/RBDA Pre-Meeting Session 1: From Discovery to Delivery: Advancing Rare Bone Disease Therapies Across the Entire Innovation Spectrum
Open to view video. | 96 minutes
Open to view video. | 96 minutes
Presentations:
From Mechanism to Medicine: The Therapeutic Journey in Rare Bone Disease (Neil Kumar, PhD)
Leveraging Infrastructure, Capital, and Expertise to Advance Therapies in Rare Disease (Sunitha Malepati, JD)
Customizing Clinical Trial Design to Rare Disorders (Emil Kakkis, MD, PhD)
ASBMR/RBDA Pre-Meeting Session 2: The Parathyroid Hormone Pathway: From Emerging Mechanisms to Evolving Therapeutics
Open to view video.
Open to view video.
Presentations:
Engineering PTH Replacement: Molecular, Biologic, and Delivery Innovations in Hypoparathyroidism (Michael Mannstadt, MD)
The Expanding Landscape of PTHR1‑Related Disorders: New Mechanisms and New Diagnoses (Jakob Hoeppner, MD)
Beyond GNAS: Evolving Understanding of Epigenetic Disorders in PTH Resistance (Murat Bastepe, MD, PhD)
The safety and efficacy of setrusumab in patients <18 years of age with osteogenesis imperfecta: 12-month results of the Phase 3 Orbit and Cosmic trials (Leanne M. Ward)
ASBMR/RBDA Pre-Meeting Session 3: Next‑Generation Tools Transforming Rare Bone Disease Research
Open to view video.
Open to view video.
Presentations:
Advancing Novel Genetic Medicine for Fibrodysplasia Ossificans Progressiva (Jae Hyuck Shim, PhD)
AI-Driven Strategies for Discovering and Repurposing Therapies in Rare Diseases (Nicholas Fragola, PhD)
From N-of-1 to Platform Therapeutics: A Roadmap for Treating Ultra-Rare Genetic Diseases (Timothy Yu, MD, PhD)
Creatine as a Novel Phosphate Regulator (Ignacio Alberto Portales Castillo, MD)
ASBMR/RBDA Pre-Meeting Session 4: It Takes an Ecosystem: The Strategic Partnerships to Unlock Rare Disease Innovation
Open to view video.
Open to view video.
Presentations:
Regulatory Pathways and Patient Voices: An FDA Perspective on Rare Bone Disease Innovation (Amy Rick, JD)
The Collaboration Imperative: Patients, Innovators, and Industry Working Together for Rare Diseases (Pamela Gavin, MBA)
Registries as Engines of Discovery and Network formation (Natasha Mireille Appelman-Dijkstra, MD PhD)
Uniting Voices, Aligning Missions: How Advocacy Leaders Build the Coalitions That Change Rare Disease Trajectories (Deborah Fowler, BA)
ASBMR Annual Meeting: Patient Organization Panel
Open to view video.
Open to view video.
Panel Presentations: Amy Rick, JD, Deborah Fowler, BA, Pamela Gavin, MBA, Natasha Mireille Appelman-Dijkstra, MD PhD
ASBMR 2026 Annual Meeting Friday 10/9/2026
Society Update and Gerald D. Aurbach Lecture
Open to view video.
Open to view video.
Presentations:
Society Update
Gerald D. Aurbach Lecture - The Ticking DNA Clock: Somatic Expansion of DNA Repeats in Human Disease (Steven McCarroll)
Highlights of the ASBMR 2026 Annual Meeting
Open to view video.
Open to view video.
Presentations:
Basic Highlights (Fanxin Long)
Clinical Highlights (Joy Y. Wu)
ASBMR/ECTS Clinical Debate: This House Believes That a T-Score Threshold of -2.5 Should Remain the Standard Criterion for Managing Osteoporosis
Open to view video.
Open to view video.
Presentations:
Michael R McClung, MD ASBMR - For the Motion
Elizabeth Martha Winter ECTS - Against the Motion
Ghada El-Hajj Fuleihan, MD, MPH, FRCP - For the Motion
Richard Eastell, MD ECTS - Against the Motion
Basic Symposium: Cell Metabolism in the Musculoskeletal System
Open to view video. | 62 minutes
Open to view video. | 62 minutes
Description: This session explores how mitochondrial function, epigenetic regulation, and metabolic flexibility shape the biology of chondrocytes, osteogenic cells, and skeletal progenitors. The talks will highlight how energy metabolism—including β-oxidation and glucose utilization—drives skeletal cell fate, function, and adaptation.
Presentations:
Chondrocytes & Epigenetics & Mitochondria (Yuuki Imai, PhD)
Osteogenic Cells - Mitochondria and B-Oxidation (Ryan C. Riddle)
Metabolic Flexibility in Glucose Utilization by Skeletal Progenitors (Steve Stegen, PhD)
Clinical Symposium: Alkaline Phosphatase Revisited - From Bench to Bedside
Open to view video.
Open to view video.
Presentations:
ALP and Biomineralization: Molecular Mechanisms in Bone Formation and Calcification (Hideo Orimo, MD, PhD)
Deep Dive into ALP: Beyond Routine Laboratory Practice (Juan Carl Pallais, MD, MPH)
Genetic Landscape of ALPL Variants: Comprehensive Overview (Kathryn McCrystal Dahir, MD)
Clinical Symposium: Next-Generation Technologies for Bone Assessment
Open to view video.
Open to view video.
Description:
Bone assessment is rapidly evolving beyond DXA alone. This session will review high-resolution imaging, AI-based fracture prediction, and emerging models of care. Faculty will discuss how new tools and clinical approaches may better identify and manage skeletal fragility. The program is designed to connect innovation in diagnostics with real-world fracture prevention strategies. Attendees will gain a practical view of the future of bone assessment and care delivery.
Keywords: Bone imaging; Artificial intelligence; Fracture prediction; Models of care; Skeletal fragility
Presentations:
High Resolution Bone Imaging: Current Clinical Applications (Steven K. Boyd, PhD)
Artificial Intelligence in Fracture Risk Assessment: Evidence and Perspectives (Namki Hong, MD, PhD)
Fracture Liaison Agents – New (Language) Models of Care (Nicholas Fuggle, MBBS, PhD)
Bench to Bedside Symposium: Muscle and Bone Interactions
Open to view video.
Open to view video.
Presentations:
Muscle-Bone Metabolism: The Dynamic Duo in Aging and Exercise (Hanna Taipaleenmaki)
Breaking the Load Myth: Resistance Training and Muscle Hypertrophy (Stuart Phillips, PhD)
Muscle Quality, Aging, and Fracture Risk: Translating Body Composition into Clinical Insight (Peggy M. Cawthon, PhD)
Basic Symposium: Osteoimmunology
Open to view video.
Open to view video.
Presentations:
Microbiome, Inflammation and Bone Loss: What Have we Learnt From Animal and Human Studies (Roberto Pacifici, MD)
Metabolic Pathways in Inflammation-Induced Ectopic Bone Formation (Chase Pagani, PhD)
Protective Neutrophil Subpopulation Reduces Inflammatory Arthritis-Related Bone Loss in Mice (Ryan MacLeod, MD, PhD)
Bone 101: Fundamentals of Bone Biology
Open to view video.
Open to view video.
Presentations:
Bone Cells and Signaling Pathways (Paola Divieti-Pajevi)
Hormonal Control of Skeletal Processes (Garyfallia Papaioannou)
Tools for Evaluating Bone Mass and Quality (Frank Ko, PhD)
Key Mouse Models Used for Bone Research (Josephine T. Tauer)
Oral Presentations: Greg Mundy Session on Cancer and Bone
Open to view video.
Open to view video.
Presentations:
Timing of PD-1/PD-L1 Blockade Determines Skeletal Toxicity and Bone Metastatic Clearance (Rachelle W. Johnson, PhD)
Roles of TUBβ2a and TUBβ3 in Metastatic Properties and Chemotherapy-Induced Bone Loss in Bone Metastatic Breast Cancer (Kayla Monae Gant, PhD Student)
Osteocyte-Driven Vascular Remodeling Primes Bone for Breast Cancer Colonization (Mattie Nester)
FGF23-KLOTHO Signaling in Myeloma Cells Drives Disease Progression (Aric Anloague, PhD, MS)
Osteosarcoma hijacks a bone stress-signaling axis to build a suppressive tumor microenvironment, reversed by host-myeloid STING activation (Elizabeth Young)
Oral Presentations: Heterotopic Ossification and Pathologic Bone Formation
Open to view video.
Open to view video.
Presentations:
Periosteal Ossification: Redefining the Cellular Sources of Heterotopic Bone in FOP (Loreilys Mejías Rivera)
Age-dependent Progression of Heterotopic Ossification and Transcriptional Responses in Fibrodysplasia Ossificans Progressiva (Nadine Z. Großmann)
Inhibition of MNK1/2-eIF4E Signaling Alleviates Pain and Reduces Heterotopic Ossification (Monisha Mittal, MS)
An O‑GlcNAc Rheostat on YAP Tunes Mesenchymal Progenitor Cell Fate in Heterotopic Ossification (Heeseog Kang, PhD)
From Tissue Repair to Heterotopic Ossification: The Degree of Somatosensory Innervation Dictates Outcomes After Injury (Sam Bae, BS)
Oral Presentations: Next-Generation Anabolic Approaches to Osteoporosis Treatment
Open to view video.
Open to view video.
Presentations:
A New Intervention for Osteoporosis: Replenishing Key Extracellular Matrix Proteins (e.g. Cyr61/CCN1) Depleted from Bone During Aging (Xiao-Dong Chen)
AAV-mediated delivery of a novel miR-39 as a novel approach to treat osteoporosis (Aijaz Ahmad John Bhat, PhD)
Wnt Surrogate Stimulates Bone Formation In Osteoporotic Mouse Models (Syeda N Lamia)
A Novel Bispecific Antibody Co-targeting TGF-β and Sclerostin for Osteoporosis Treatment (Ahyoun Choi, PhD)
Osteoanabolic Actions of Intermittent Parathyroid Hormone (PTH) Require Bone Marrow Adipocyte Lipolysis (Kateryna Nabukhotna, PhD)
Oral Presentations: Skeletal Stem and Progenitor Cell Regulation in Bone Homeostasis and Repair
Open to view video.
Open to view video.
Presentations:
Bone marrow adipoprogenitors, not mature adipocytes, primarily regulate bone remodeling and hematopoiesis (Michael Duffy, PhD)
CBFβ-INO80 Chromatin Remodeling Preserves Aged Marrow Adipoq+ Skeletal Progenitors and Bone Repair (Mengrui Wu)
Multi-modal Transcriptomics reveals site-specific skeletal stem/progenitor cell (SSPC) Dynamics in Abaloparatide-treated fractures (Ashutosh Parajuli, PhD)
DNMT1 Integrates Aging and Mechanical Unloading Signals to Control BMSC Fate and Skeletal Adaptation (Yangguang Li, MS)
Dot1L Histone Methyltransferase Activity Regulates Skeletal Stromal Progenitor Activation and Osteogenic Lineage Competence During Bone Homeostasis and in Response To Injury (Marta Stetsiv, BS, PhD, MD)
Oral Presentations: Sugar, Fat, and Fracture: The GLP-1 Era of Bone Health
Open to view video.
Open to view video.
Presentations:
Unsaturated Bone Marrow Lipids Have Negative Effects on Bone Quality in Individuals with Type 2 Diabetes (Minhao Zhou, PhD)
Serum biomarkers and histomorphometric bone turnover in adults with type 1 diabetes and chronic kidney disease (Clarence Chu, MD)
Fracture Risk Among GLP-1 Receptor Agonists and Other Anti-Hyperglycemic Agents: A Compound-Level Analysis in Women ≥50 Years with Type 2 Diabetes (Jawaad Shahid Chaudhry, BS)
Fracture risk associated with incretin-based therapies in people living with overweight or obesity: a Bayesian meta-analysis of placebo-controlled randomized trials (Julien Paccou, PhD, MD)
Semaglutide Use and Risk of Osteoporosis, Osteopenia, and Fracture in Non-Diabetic Postmenopausal Women with Obesity: A Retrospective Cohort Study
Jessica Siguencia, BS
ASBMR 2026 Annual Meeting Saturday 10/10/2026
Louis V. Avioli Lecture and Esteemed Awards Presentations
Open to view video. | 100 minutes
Open to view video. | 100 minutes
Presentation:
Louis V. Avioli Lecture - Calcium and Phosphate Physiology: Translating Findings to the Clinic
(Michael T Collins, MD)
Basic Symposium: Novel Factors Driving Bone Metastasis
Open to view video.
Open to view video.
Description:
Metastasis to bone remains a clinical challenge and it significantly affects the quality of life and survival of patients. Metastatic cancer cell fate is shaped by organ-specific microenvironments. This session examines how osteolineage-derived cells contribute to the remodeling of the bone metastatic niche and the emergence of tumor-supportive cancer-associated fibroblasts (CAFs). Moreover, the impact of immune cells will be discussed in the bone metastatic process.
Presentations:
Osterix+ Osteolineage Cells Are a Source of Tumor-Promoting myCAFs in Breast Cancer (Giulia Furesi, PhD)
Osteolineage-Derived CAFs Reshape the Bone Metastatic Niche (Jennifer Zarrer)
Targeting Niche-Specific Alterations in Bone Metastasis (Igor L Bado, PhD)
Clinical Symposium: Phosphate Dynamics: From Basics to Bone Disorders
Open to view video.
Open to view video.
Description:
Phosphate is a central signal in skeletal and mineral metabolism. This session connects core phosphate biology with rare bone disease and CKD-MBD. Faculty will review FGF23-mediated disorders and tumor-induced osteomalacia. The program will also address phosphate toxicity and systemic consequences in CKD. Attendees will gain a clinically integrated view of phosphate-related bone disease.
Keywords: Phosphate; FGF23; Tumor-induced osteomalacia; CKD-MBD; Mineral metabolism
Presentations:
Phosphate-Sensing Mechanisms and Functions of Phosphate as a First Messenger (Yuichi Takashi, MD., PhD)
FGF23-Driven Rare Bone Disease: Treatment Advances (Kelly Lauter Roszko)
Regulators of FGF23 in CKD: Phosphate, Iron/EPO, and Systemic Consequences (Erica L Clinkenbeard, PhD)
Public Outreach Session: An Owner’s Manual for the Skeleton: Protecting Your Bones Through Movement, Medicine, and Menopause
Open to view video.
Open to view video.
Description:
Join leading bone health experts for an engaging, easy-to-understand conversation about keeping your bones strong throughout life. You'll hear practical advice you can put into action, learn when to talk with your healthcare provider about bone health, and leave feeling more informed about how to support your long-term health.
Presentations:
Talking to Your Physician About Bone Health (Eric S. Orwoll)
Exercise and Bone Health (Lora M. Giangregorio, PhD)
Menopause (Joy Tsai, MD)
Oral Presentations: Advances in Osteocyte Biology: Mechanotransduction, Metabolism, and Matrix Regulation
Open to view video.
Open to view video.
Presentations:
Mechano-metabolic axis involves mitochondrial responses via BMP/Smad regulatory effect on cyclophilin D (Roman A. Eliseev)
Interrogating the Impact of Sclerostin Monoclonal Antibody Treatment on Osteocyte Mechanosensitivity In Vivo (Andi Sarai Garcia-Ortiz, MS)
Disuse Increases Cancellous and Cortical Bone Responses to Mechanical Loading by Enhancing Lacunocanalicular Fluid Dynamics (Haisheng Yang, PhD)
MeSo-Cre: A new Cre-driver line employing a permissive 2-promoter/2-recombinase strategy to target Cre to the osteocyte population with high fidelity (Alexander G. Robling, PhD)
ENPP1 is a direct SP7-regulated target in osteocytes and bone extracellular matrix mineralization (Jialiang Wang, PhD)
Oral Presentations: Hormonal Networks Governing Bone and Phosphate Physiology
Open to view video.
Open to view video.
Presentations:
FGF23 produced from sinusoidal endothelial cells controls hematopoiesis, adipose mass, and bone quality in anemic mice (Jackie A. Fretz, PhD)
N-terminal FGF23 Peptide Is Sufficient to Correct Bone and Mineral Metabolism in Fgf23 Null Mice (Eduardo Duque, PhD, MD)
ETV1 unifies genomic endocrine regulation of vitamin D metabolism by FGF23 and PTH (Eileen Sember)
Restoration of parathyroid hormone receptor (PTH1R) localization to the primary cilium reverses the impaired osteocyte mechanosensitivity in diabetes mellitus (Joan Pizarro Gomez, PhD)
Oral Presentations: John H. Carstens Memorial Session
Open to view video.
Open to view video.
Presentations:
The Effects of 3-Months of Romosozumab Followed By 21-Months of Denosumab Versus 12-Months of Romosozumab Followed By 12-Months of Denosumab on BMD in Postmenopausal Osteoporotic Women: The LIDA-Extension Study (Benjamin Z. Leder, MD)
Premenopausal women with idiopathic osteoporosis have continued BMD increases with sequential romosozumab-denosumab therapy (Lauren Kelly Lynch, PhD, MD)
Pretreatment High Bone Turnover Phenotype Is Associated With Greater Bone Mineral Density Gains During 5-Year Denosumab Treatment (Koji Ishikawa, PhD)
Integrated Effects of Vitamin D, Omega-3 Fatty Acids, and Exercise on Bone and Muscle Health in Generally Healthy Older Adults: Results from the DO-HEALTH Trial (Heike Annette Bischoff-Ferrari)
Comparative Risk of Osteonecrosis of the Jaw With SERMs, Bisphosphonates and Denosumab in Osteoporosis: A Nationwide Target Trial Emulation Study (Kyoung Jin Kim, PhD)
Oral Presentations: Molecular Regulation of Osteoblast Function and Bone Formation
Open to view video.
Open to view video.
Presentations:
Bmp and Activin Membrane-Bound Inhibitor (Bambi), a Novel PTH Target Gene in Osteocytes, is Required for Dendrite formation and for Cortical Bone Integrity and Skeletal Homeostasis in Mice (Kalpana Patel, PhD)
SLC22A17 Is Required for Lipocalin-2-Mediated Suppression of Wnt/β-Catenin Signaling in Bone (Vivek S. Khanal, PhD)
11β-HSD1 Regulates Osteoblast Proliferation and Bone Remodeling Through Modulation of Wnt/β-Catenin Signaling (Husam Bensreti, PhD)
Glucose Oxidation in Mitochondria is Dispensable for Bone Formation (Jasmin Koehnken Sawall, PhD)
Fra2/AP-1 in B Cells Is a Key Regulator of Osteoblastogenesis in Bone Remodeling (Flora Nguemedjio Foko Takile)
Oral Presentations: Osteoclasts at the Interface of Skeletal and Hematopoietic Regulation
Open to view video.
Open to view video.
Presentations:
Bone Resorptive Microenvironment Fosters Macrophage-Hematopoietic Stem Cell Interactions That Safeguard Red Blood Cell Regeneration (Ryan Adapathya)
Physiological bone remodeling shapes a non-uniform inflammatory landscape of marrow macrophages that regulates Tet2+/- mediated clonal blood disorders (Kevin Lee)
Targeting SRPK1 brakes energy metabolism of osteoclasts by regulating alternative splicing (Qingliang Ma, MD)
Intermittent parathyroid hormone employs osteoclast-dependent mechanisms to drive osteogenesis from Ebf3-expressing skeletal progenitor cells (Byron S K Chan, PhD)
Angiogenin-Mediated Mitochondrial Biogenesis Is Required for Osteoclast Fusion (Ke Shen, MD)
Oral Presentations: Pathway-Targeted Approaches to Skeletal Dysplasia
Open to view video.
Open to view video.
Presentations:
Mitochondrial dysfunction plays a key role in premature musculoskeletal aging in hypochondroplasia mouse model (Chantal Fayad, PhD student)
Prenatal Treatment with Dabogratinib Increases Both Long Bones and Size of the Foramen Magnum and Delays Premature Fusion of Synchondroses in a Mouse Model Mimicking Achondroplasia (Jacqueline Starrett, PhD)
Appendicular and cranial base skeletal defects in Achondroplasia are ameliorated by treatment with a retinoid drug as revealed in a mouse model (Christina Mundy, PhD)
PTH1R agonist treatment improves growth plate architecture and promotes skeletal growth in Achondroplasia model mice (Prem Swaroop Yadav, PhD)
An orally available small-molecule inverse agonist to reduce constitutive activity of PTH1R mutants that cause Jansen’s metaphyseal chondrodysplasia (Jakob Hoeppner, MD)
Oral Presentations: Smarter Fracture Risk Prediction: AI and Biomarkers Across Populations
Open to view video.
Open to view video.
Presentations:
Hematological Markers and Fracture Risk Independent of Bone Mineral Density: Evidence from the UK Biobank (Jeonghoon Ha, PhD, MD)
Associations of Circulating Inflammatory Markers with Bone Microarchitecture in Older Men: Findings from the MrOS Study (Malak Faraj, PhD)
Clinically Interpretable Predictors of Imminent Subsequent Fractures in a Deep-Learning Prediction Model (Jacqueline R. Center, MD, PhD)
A Novel Deep Learning Application to Predict High-risk Fracture Patients for Imminent Non-Fracture Re-Hospitalizations (Jacqueline R. Center, MD, PhD)
Racial and Ethnic Differences in Clinical Indications for Osteoporosis Treatment in U.S. Women: A Population-Based Cohort Study (Adele Carty, PhD, MSc)
Oral Presentations: Spatial Bone Marrow Microarchitecture
Open to view video.
Open to view video.
Presentations:
High-Resolution Spatial Transcriptomics Reveals Distinct Cellular Niches and Aging Remodeling in Murine Femoral Bone Marrow (Lutian Yao, MD)
Spatial Deconvolution of the Bone Microenvironment and Inflammatory Niches using a Transcriptomic-Driven Segmentation and Cell Simulation Approach (Visanu Wanchai)
Single Cell Spatial Transcriptomics Maps Region-Specific Diversity of Human Skeletal Stem Cells (Kun Chen, PhD, MD)
Intravital Imaging of Connexin 43 (Cx43)-regulated Calcium Network Topology Reveals Immune-Modulatory Loci and Regulates Bone Homeostasis in the Bone Marrow (Cih-Li Hong, DVM, PhD student)
Dysbiosis of the Aged Gut Drives Myeloid Bias by Altering the Skeletal Stem Cell Niche (Kelly Weldon, MD/PhD student)
Oral Presentations: Tackling Fibrous Dysplasia: From FGF Signaling to Real-World Therapy
Open to view video.
Open to view video.
Presentations:
Raman Spectroscopy Identifies Consistent And Marked Extracellular Matrix Abnormalities In Fibrous Dysplasia Lesions (Lucie Levaillant)
Repression of FGF Signaling as a Potent Therapeutic Strategy for Fibrous Dysplasia (Rinna Kanai, PhD Student)
A Phase 2 trial of Denosumab for Prevention of Skeletal Disease Progression in Children with Fibrous Dysplasia (Vivian MacDonald)
Identifying Novel Therapies for Fibrous Dysplasia of the Bone Using a Transcriptomics-Based Computational Drug Repurposing Strategy (Jeayoung Park, MD)
Burosumab In The Treatment Of Fgf-23 Induced Hypophosphatemia In Fibrous Dysplasia Of Bone – A Real-World Study In 11 Patients (Roland Chapurlat, MD, PhD)
Oral Presentations: The Systemic Disease–Bone Interface
Open to view video.
Open to view video.
Presentations:
Trabecular Bone Score In Children With Duchenne Muscular Dystrophy: TBS Osteo Advanced For Pediatrics (Anna N.H. Walstra, PhD Student)
Development of a Fracture Prediction Model for Patients Aging with HIV (Evelyn Hsieh, MD, PhD)
Target-Trial Emulation Identifies ARB/Statin Protective Signals and Clinically Interpretable Fracture-Risk Signals in Osteoporosis (Jianing Liu)
Fracture Risk and Post-Fracture Mortality with Chronic Proton Pump Inhibitor Use: Findings from the OSIRIS Nationwide Study (Cecile Philippoteaux, MD, PharmD, PhD)
Mapping disease trajectories preceding hip fracture: a population-based analysis from Hong Kong and the United Kingdom (Ching-Lung Cheung, Ph)
ASBMR 2026 Annual Meeting Sunday 10/11/2026
Plenary Symposium: Incretins and Musculoskeletal Health
Open to view video.
Open to view video.
Description:
Incretin-based therapies are rapidly reshaping clinical practice, with important implications for musculoskeletal health. This session will examine the physiology and mechanisms of GLP-1- and GIP-based therapies, with attention to the key clinical questions that arise as their use continues to expand. Faculty will review current evidence on the effects of GLP-1 receptor agonists on bone and muscle, including factors that may influence musculoskeletal risk during treatment. The program will also address why bone vulnerability may emerge during medical and surgical weight loss, and how clinicians can protect skeletal health in these settings. Attendees will gain a practical and up-to-date framework for understanding incretins and musculoskeletal risk.
Keywords: GLP-1; GIP; Musculoskeletal health; Bone and muscle; Weight loss
Presentations:
Esteemed Awards Presentations
GLP-1 and GIP Therapies: Physiology, Mechanisms, and Clinical Relevance (Morten Frost Frost, PhD)
Bone and Muscle Effects of GLP-1 Receptor Agonists (Guillaume Mabilleau)
Bone Protection During Medical and Surgical Weight Loss (Kristen Marie Beavers, PhD)
ASBMR/ ORS Basic Debate: The Effect of Mechanical Loading on Bone is Primarily Mediated by Osteocytes - For or Against?
Open to view video.
Open to view video.
Presentations:
Matthew J. Silva, ORS: For the Motion
Ryan E Tomlinson, PhD, ASBMR: Against the Motion
ORS Rebuttal
ASBMR Rebuttal
Question and Answer
Restatements
Summary and Voting
Basic Symposium: New Roles of the FGF23-HIF/Oxygen Axis in Bone
Open to view video.
Open to view video.
Presentations:
Iron/FGF-23/Erythroid HSC Mobilization (Valentin David)
Erythroid Precursors Regulate Local Oxygen Tension and Repair Outcomes in the Bone Marrow Niche (Annemarie Lang, PhD, DVM)
HIFs and Bone/Bone Marrow (Colleen Wu, PhD)
Oral Presentations: Calcium Homeostasis Disorders: Phase 3 Breakthroughs and Precision-Driven Care
Open to view video.
Open to view video.
Presentations:
Genotype-First Approach to Estimate the Prevalence and Characterize the Phenotypic Spectrum of Familial Hypocalciuric Hypercalcemia Type 1 (Nipith Charoenngam,
MD)
Encaleret Restores Mineral Homeostasis And Increases Bone Turnover In Autosomal Dominant Hypocalcemia Type 1 (ADH1): 24-Week Results From Phase 3 CALIBRATE Trial (Erik Imel)
Participant-Reported Changes in Symptoms and Treatment Experience with Encaleret in Autosomal Dominant Hypocalcemia Type 1: 24-Week Findings From the Phase 3 CALIBRATE Trial (Steven Wai Ing, MD)
Balanced Effects of Eneboparatide on Skeletal Parameters: Results From a Phase 3, Randomized, Placebo-Controlled Study Evaluating the Efficacy and Safety of Eneboparatide in Adults With Chronic Hypoparathyroidism (CALYPSO) (Aliya Aziz Khan, MD)
Long-Term Effects of Palopegteriparatide on BMD and TBS in Adults With Chronic Hypoparathyroidism: Pooled Results From the PaTH Forward and PaTHway Trials
(Aliya Aziz Khan, MD)
Clinical Symposium: Challenging Subjects in Osteology
Open to view video.
Open to view video.
Description:
Some of the most important skeletal problems in practice are also the easiest to overlook. This session addresses restrictive eating disorders (anorexia nervosa and ARFID (avoidant/restrictive food intake disorder), perioperative bone care, and genetic causes of early fragility. Faculty will focus on recognition, assessment, and practical management. The program highlights scenarios that often fall outside routine osteoporosis care. Attendees will gain sharper clinical insight into challenging osteologic presentations.
Keywords: Eating disorders; Perioperative bone care; Genetic bone disorders; Skeletal fragility; Osteology
Presentations:
The Hidden Skeletal Cost: Bone Health in Eating Disorders (Catherine M. Gordon)
Perioperative Management of Bone Health in Orthopedic Patients (Emily Margaret Stein, MD)
Early Skeletal Fragility Identifying Genetic Bone Disorders (Ralf Oheim)
Clinical Symposium: Comprehensive Osteoporosis: Mastering Complex Management Strategies
Open to view video.
Open to view video.
Description:
Osteoporosis management increasingly depends on strategy, not only drug selection. This session will address sequencing, zoledronic acid, and denosumab discontinuation. Faculty will discuss some of the most difficult real-world management scenarios. The emphasis will be on practical approaches informed by evolving evidence. Attendees will gain clearer frameworks for complex osteoporosis care.
Keywords: Osteoporosis; Treatment sequencing; Zoledronic; Denosumab; Fracture prevention
Presentations:
Sequencing Matters: Strategic Treatment Planning for Optimal Outcomes (Benjamin Z. Leder, MD)
Rethinking Zoledronate: When, How, and for Whom? (Bente L. Langdahl, DSc., PhD, MD)
The Denosumab Dilemma: Unresolved Questions Regarding Management Strategies for Denosumab Discontinuation (Adi Cohen, MD, MS
Oral Presentations: ASBMR/OARSI Oral Presentation: Molecular Mechanisms of Osteoarthritis Development
Open to view video.
Open to view video.
Presentations:
Osteocyte Parvalbumin Mediates Mechanotransduction to Attenuate Osteoarthritis (Jiansen Su, MD, PhD Student)
GNL3 Maintains Nucleolar−Chromatin Integrity to Suppress ERV−driven Innate Immune Activation in Osteoarthritis (Yaguang Zhao, PhD)
LOXL2 as a master regulator of inflammation, cartilage homeostasis, and pain in knee and TMJ osteoarthritis (Manish V Bais, PhD)
Targeted degradation of Nav1.7 by PROTAC attenuates cartilage degeneration and pain in osteoarthritis (Wenyu Fu, PhD)
Dysregulation of Chondrocyte-mediated Endochondral Ossification Contributes to The Developmental Osteopetrosis Bone Phenotype in Lrrk1 Knockout Mice (Anakha Udayakumar)
Oral Presentations: Cancer and Bone Tumor–Immune–Bone Interactions in Disease Progression and Therapy
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Open to view video.
Presentations:
Denosumab Discontinuation in Breast Cancer Survivors (Monica Fornier, MD)
Anti-RANKL Enriches for Immunosuppressive Bone Marrow Myeloid Populations in Breast Cancer Bone Metastases (Jailyn Smith)
Bone-Derived TGF-β Promotes Anaplastic Thyroid Cancer Bone Metastases: Therapeutic Effects of Zoledronate and Bone-Targeted TGF-β Inhibition on ATC-Bone-Immune Microenvironment (Shiyu Yuan, PhD)
CART Therapy is Associated with Altered Bone Microarchitecture in Multiple Myeloma (Anders Narum)
Fracture Risk Associated with Immune Checkpoint Inhibitor Therapy: A Population-Based Matched Cohort Analysis Using Administrative Health Data (Carrie Ye, FRCP)
Oral Presentations: Cellular and Bioengineering Approaches to Bone Repair
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Open to view video.
Presentations:
CXCL9 Neutralization Enhances Aged Fracture Repair and Rebalances CXCL12 Signaling in the Periosteal Niche (Matthew Daniel Wan, BS, PhD Student)
Muscle-derived CX3CL1 promotes bone repair through CX3CR1-expressing osteoprogenitors (Koji Ishikawa, PhD)
Macrophage YAP/TAZ Signaling Mediates Mechanoregulation of Bone Fracture Repair (Georgios Kotsaris)
An Implantable Biobattery for In Situ Critical-Sized Bone Regeneration via Chemical-to-Biological Energy Conversion (Duoyi Zhao)
Targeting ACLY-Mediated Fatty Infiltration with Hydrogel Microneedles Promotes Tendon-Bone Healing After Rotator Cuff Injury (Mingjie Ma)
Oral Presentations: Cellular and Microenvironmental Drivers of Skeletal Aging
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Open to view video.
Presentations:
Depletion of a detrimental subset of senescent cells by conditional knockout of CXCR2 in p16INK4a (p16) expressing senescent cells improves fracture repair (Yiwei Lu, BS)
Low Burdens of Senescent Osteocytes Establish Distance-Dependent Mechano-Inflammatory Niches in 3D Co-Culture (Hossein Shaygani)
MMP12 drives senescence-related bone loss via the cGAS-STING pro-inflammatory pathway (Abhishek Chandra, PhD, MS)
Aged-related Impairment of Bone Matrix can be Transferred to Young Mice through the Gut Microbiota (Natasha Katharine Hunt, BS, MS)
Mechanosensitive Piezo1–YAP–CCN Signaling in Osteocytes Prevents Skeletal Aging (Yizhong Hu)
Oral Presentations: Cracking Clinical Cases
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Open to view video.
Presentations:
Combination Therapy for Gorham-Stout Disease: A Case Report (Fiona Kirkham-Wilson)
A Case of Severe Recurrent Hypophosphatemia due to Hyperventilation (Iris Hartley)
A Paradoxical Complication: Calciphylaxis as a Novel Adverse Effect of Asfotase Alfa in Hypophosphatsia (Smriti Madaan, MD)
"Hangry” Bone Syndrome: Novel Management of Refractory Hypocalcemia in Pseudohypoparathyroidism Type 1A (Patrick Cacchio, PA)
Reclassifying a TNFRSF11A Variant: Three-Generation Osteolytic Disease with Zoledronic Acid Response (Kamran Huseynli, MD)
Oral Presentations: Genetic Prediction and Stratification of Fracture Risk
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Open to view video.
Presentations:
Personalized fracture risk assessment with a focus on hip and vertebral fractures: validation of the HiVe fracture risk score in men from the MrOs study cohort (Claus Christian Glueer, PhD)
Increased Gluteofemoral Fat Elevates Fracture Risk through Bone Mineral Density Reduction in Two-sample Mendelian Randomization Study (Hye Kong, PhD, MD)
Genetic Clustering of Bone Mineral Density Loci Reveals Heterogeneous Mechanistic Pathways Associated with Osteoporosis (Nipith Charoenngam, MD)
Polygenic Risk and Ancestry-Specific Genetic Effects Drive Hip Bone Mineral Density Prediction (Martha Isabel Gonzalez Ramirez)
Multi-Omic Dissection of Fragility Fractures Identifies Systemic Aging Signatures and Novel Ancestry-Specific Targets (Hongyu Wang, PhD Student)
Oral Presentations: Multi-Omics and Regulatory Genomics in Skeletal Biology
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Open to view video.
Presentations:
Decoding Skeletal Genetics with a Bone Atlas of Genetic Regulatory Effects (Kristyna Kupkova, PhD)
Multi-Omics Integration Reveals Regulatory Biomarkers Associated with Bone Mineral Density Variation in Men (Boluwatife Lawrence Afolabi, BTech., MSc)
High-Definition Spatial Transcriptomics of Mouse Femoral Head Integrated with GWAS Reveals Bone-Muscle Crosstalks and Genetic Risk for Osteoporosis (Yuwei Hou, MP)
Identification of a skeleton specific DLX5 distal enhancer and involvement of the enhancer in bone homeostasis (Shinse Fujita, MD., PhD)
SERPINA1-Associated Alpha-1 Antitrypsin Deficiency Reduced Vertebral Bone Structure and Mediated Bone Cells Toward Osteoporosis (Neharika Bhadouria)
[Recording Coming Soon] Oral Presentations: New Insights into Bone Development
Open to view video. | 60 minutes
Open to view video. | 60 minutes
Presentations:
APOE regulates lipid droplet metabolism in resting chondrocytes to drive longitudinal bone growth (Kenji Takami)
Cellular-resolution spatial transcriptomics reveals an orthogonal PTHrP-GDF5 signaling axis in early endochondral bone development (Shion Orikasa)
Spatiotemporal Dynamics of An Endochondral Skeletal Stem Cell Subtype Governs Skeletal Morphogenesis and Regenerative Potential
(Yuting Wang, PhD, MD)
Identification of the METTL16-m⁶A-YTHDC1 Axis as an Epitranscriptomic Regulator of Limb and Craniofacial Development via Chromatin Regulation (Zhong Zhang)
Loss of PRDM16 Drives Nasal Septal Deviation via Dysregulated TGFβ2 Signaling (Eliya Tazreena Tashbib, PhD)
Oral Presentations: Therapeutic Advances Across Rare Bone Diseases
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Open to view video.
Presentations:
Efficacy and Safety of Alkaline Phosphatase (ALP) Enzyme Replacement Therapy (ERT) Efzimfotase Alfa in Adolescents and Adults with Hypophosphatasia (HPP): Results of HICKORY as Part of a Three-Trial Phase 3 Clinical Program (Raja Padidela, MD, MBBS)
The safety and efficacy of setrusumab in patients <18 years of age with osteogenesis imperfecta: 12-month results of the Phase 3 Orbit and Cosmic trials (Leanne M. Ward)
Treatment with high dose sclerostin neutralizing antibody improved mechanoregulation in adults with severe osteogenesis imperfecta (Bettina M. Willie, PhD)
The Impact of the Inhibition of Activin A by the Neutralizing Antibody Garetosmab for the Resolution of Nascent Heterotopic Bone Lesions in FOP Mice and People with FOP (Dinko Gonzalez Trotter, PhD)
Repurposing Denosumab as Treatment for Adult Langerhans Cell Histiocytosis: Long Term Follow-Up (Polyzois Makras)
ASBMR 2026 Annual Meeting Monday 10/12/2026
Plenary Symposium: International Perspectives on Bone Health & Highlights of the Year in Skeletal Biology and Esteemed Awards Presentations
Open to view video. | 106 minutes
Open to view video. | 106 minutes
Presentations:
Esteemed Awards Presentations
Reimagining Routine Health Information Systems to Detect Fracture Risk and Osteoporosis: A Technical Report Prepared for the World Health Organization (WHO) (Marc Sim, PhD)
Disparities in Fragility Fracture and Osteoporosis Care in Africa (Kate A. Ward, PhD)
Epidemiology of Osteoporosis in Asia: Regional Disparities and Global Impact (Ching-Lung Cheung, PhD)
Year in Review: Basic & Clinical (Michael Mannstadt, MD)
ASBMR/BMAS Symposium: BMAT
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Open to view video.
Description:
Bone marrow adipose has emerged as a unique fat depot with endocrine functions. Moreover, it is an important support structure for hematopoiesis. Yet, how it is regulated during health and disease, how it interacts with its environment, and if there are sex-specific differences is not fully understood. In this session, insights will be provided on the sex- and site-specific regulation of BMAT in humans and in mice, and a novel mouse model will be introduced to study BMAT.
Presentations:
Mechanisms of BMAT Expansion During CR Including Novel Mouse Models and Diets (Isabel Dorothy Kane Hermsmeyer, MS)
Site-specific metabolic profiles of BMAT (Drenka Trivanovic, PhD)
Genetic architecture and clinical implications of bone marrow adiposity in the UK Biobank: a meta-GWAS and MR-PheWAS study (Wei Xu)
Bench to Bedside Symposium: Translating Genomics Discoveries into Meaningful Clinical Outcomes
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Open to view video.
Presentations:
Polygenic Risk Scores and Clinical Fragility (Carolina Medina-Gomez, PhD)
From Beside Back to Bench: How Genetics Are Reshaping Drug Development (Lon R Cardon, PhD)
Translating Genomics into Clinical Outcomes: Pharmacogenomics, Rare Variants & Scalability (Yvonne Bombard, PhD
Oral Presentations: Bone at the Interface of Interorgan Communication
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Open to view video.
Presentations:
Bone-derived PDGF-BB Impairs Amyloid-β Clearance in the Brain (Jiekang Wang, MS)
Preclinical Evaluation of an FSH-Blocking Therapeutic Antibody for the Treatment of Osteoporosis, Obesity, and Alzheimer’s Disease (Satish Rojekar, PhD)
Conditional Osteoblast D2 Receptor Deletion Rescues Diabetic Bone Disease in Mice (Yaser Peymanfar, PhD)
Disrupted lipid homeostasis underlies bone fragility in diabetes, which is corrected by pharmacological activation of the transcription factor LXR (Nisreen Akel, BS)
Osteocytic ENPP1 Mediates Bone–Liver Crosstalk and Induces Fatty Liver Disease by Promoting Lysosomal Secretion of Spermine Synthase (Chang Liu, PhD, MD)
Lymphatic VEGFD Signaling Orchestrates T Cell-Dependent Bone Remodeling after Injury (Neda Vishlaghi, PhD)
Oral Presentations: Pathway Therapeutics in Rare and Genetic Bone Disease
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Open to view video.
Presentations:
C-type natriuretic peptide (CNP) agonist CNP38 promotes longitudinal bone growth by growth plate expansion in the Hyp mouse model of XLH (Hailey Rose Bruneau)
ENPP1 Inhibition Improves the Bone Phenotype, Mobility, Muscle Strength and Endurance in Later-Onset HPP Mice (Valeria Guglielmi)
Autophagy Stimulation Improves Bone Formation and Restores Cortical Thickness of a Murine Model of Osteogenesis Imperfecta (Alicen James)
Romosozumab Improves Bone Material Quality in Osteogenesis Imperfecta (Bowen Wang)
Romosozumab is associated with large BMD increases in premenopausal osteoporosis with and without osteoporosis-related genetic findings (Lauren Kelly Lynch, PhD, MD)
Plasma Proteomics Distinguishes Clinical Expression in ADO and Highlights Differential Inflammatory and Matrix Remodeling Pathways (Jeffrey Mital, PhD)
Oral Presentations: The Aging Skeleton in High Resolution
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Open to view video.
Presentations:
Deterioration of Bone Microarchitecture Across the Menopause Transition Assessed by High-Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) (Alyssa B. Dufour, PhD)
Time-lapse HR-pQCT Reveals Rapid Cortical Bone Loss With Localized Periosteal Apposition and Subperiosteal Circumferential Pore Formation in Older Men (Minhao Zhou, PhD)
Longitudinal Changes in Bone Microarchitecture According to Age, Sex, and Diabetes Status Using High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) (Chandler Da Cruz, BS)
Patient-Specific Probability of Hip Fracture as Assessed by BCT to Identify Women and Men Age 65 and Older Who are at High and Very High Risk of Hip Fracture (Tony M. Keaveny, PhD)
Magnetic Resonance Imaging-derived novel vertebra-disc-scores (VDS) for assessing osteoporosis and vertebral fracture risk (Haisheng Yang, PhD)
Bone Strength Assessment Using Magnetic Resonance Imaging (MRI) Compared to High-resolution Peripheral QCT (HR-pQCT) (Chamith S. Rajapakse, PhD)
Late-Breaking Oral Presentations: Basic Science
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Open to view video.
Presentations:
Senescent Osteocyte-Derived CXCL2 Drives Age-Related Osteoporosis via FOXO3/SLC7A11-Dependent Ferroptosis in Osteoclast Precursors (Qiangqiang Li)
Reduced PDGF-BB/PDGFRβ Signaling in LEPR+ Osteoprogenitors Contributes to Skeletal Fragility in Experimental Type 2 Diabetes (Cyril Thouverey, PhD)
PTH receptor activation restores pro-osteogenic transcriptional program and Wnt signaling in diabetic bone and stimulates osteocyte-to-preosteoblast communication through Wnt5b-Fzd5 ligand-receptor interactions.
Sudipta Baroi, PhD, BS, MS)
Pentose Phosphate Pathway-Rewired Neutrophils Sabotage Diabetic Bone Healing via LCN2-Mediated Osteogenic Suppression (Ruiying Chen, PhD, DDS)
ANK and ABCC6 Cooperatively Regulate Extracellular Pyrophosphate and Citrate Homeostasis to Control Soft Tissue Calcification and Bone Quality (Koen Van De Wetering, PhD, DVM)
Metformin alleviates osteoarthritis and chondrocytes senescence by HDAC5/mTOR/autophagy regulatory axis (Xiaoling Zhang, PhD)
Late-Breaking Oral Presentations: Clinical Science
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Open to view video.
Presentations:
Abaloparatide with Continued Denosumab Versus Continued Denosumab Alone (ACTED Study) (Felicia Cosman, MD)
Zoledronate to Reduce Fractures in People with Parkinson’s Disease or Atypical Parkinsonism. A Home-based Randomized Trial (Steven R. Cummings, MD)
Circulating Cellular Communication Network Factor 3 Predicts Maternal Skeletal Recovery During Lactation (Muriel E. Babey, MD)
The Long-Term Safety and Efficacy of Garetosmab in Adults with Fibrodysplasia Ossificans Progressiva: Week 84 Results From the Phase 3 OPTIMA Study (Richard W. Keen, MD PhD)
Finding the Optimal Resistance Training Intensity for Your Bones (FORTIFY Bones): A Randomized Controlled Trial (Lora M. Giangregorio, PhD)
Effects of Limited versus Standard Dose Romosozumab followed by Denosumab on Peripheral Bone Density and Microarchitecture: The LIDA-HRpQCT Extension study (Joy Tsai, MD)
