Long-Term Osteoporosis Treatment: Osteoclasts Biology

This topical learning module encompasses the formation, fusion, resorption, and signaling processes of osteoclasts to osteoblasts (coupling), along with the modulation of these processes by long-term antiresorptive therapy (e.g., RANKL inhibition). The available resources encompass Primer textbook chapters, ASBMR webinars/meeting sessions, podcasts, and recent JBMR/JBMR Plus articles on osteoclast mechanisms relevant to sustained therapy and treatment discontinuation.

Component List: 

  • Primer (10th Edition) Chapter 
  • Webinar: ASBMR Educational Series on Denosumab Therapy in Osteoporosis and Cancer - Episode 1
  • Webinar: ASBMR Educational Series on Denosumab Therapy in Osteoporosis and Cancer - Episode #2
  • JBMR Article: Osteoclast-derived coupling factors: origins and state-of-play Louis V Avioli lecture
  • JBMR Article: Temporal patterns of osteoclast formation and activity following withdrawal of RANKL inhibition
  • JBMR Article: The effects of denosumab on osteoclast precursors in postmenopausal women: a possible explanation for the overshoot phenomenon after discontinuation
  • JBMR Article: Osteal macrophages support osteoclast-mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model
  • JBMR Plus Article: New Insights Into Osteoclast Biology


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    Denosumab Therapy in Osteoporosis and Cancer - Episode 1
    Open to view video.  |  60 minutes
    Open to view video.  |  60 minutes Paul Kostenuik, Ph.D., consultant and contract medical writer for the biotechnology, pharmaceutical, and device industries (DBA Phylon Pharma Services), and Adjunct Professor at the University of Michigan School of Dentistry discusses mechanisms by which current osteoporosis therapies (bisphosphonates and denosumab) work to inhibit osteoclast activity. This webinar series is supported in part by an educational grant from Amgen Inc.
    You must register to access.
    Denosumab Therapy in Osteoporosis and Cancer - Episode #2
    Open to view video.  |  60 minutes
    Open to view video.  |  60 minutes Join us as Bente Langdahl, M.D., Ph.D., Clinical Professor at Aarhus University, and Elena Tsourdi, Ph.D., Senior Consultant at the University Dresden Medical Center, to discuss denosumab discontinuation.
    You must register to access.
    JBMR Article: Osteoclast-derived coupling factors: origins and state-of-play Louis V Avioli lecture
    Open to download resource.
    Open to download resource.
    You must register to access.
    JBMR Article: Temporal patterns of osteoclast formation and activity following withdrawal of RANKL inhibition
    Open to download resource.
    Open to download resource.
    You must register to access.
    JBMR Article: The effects of denosumab on osteoclast precursors in postmenopausal women: a possible explanation for the overshoot phenomenon after discontinuation
    Open to download resource.
    Open to download resource.
    You must register to access.
    JBMR Article: Osteal macrophages support osteoclast-mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model
    Open to download resource.
    Open to download resource.
    You must register to access.
    JBMR Plus Article: New Insights Into Osteoclast Biology
    Open to download resource.
    Open to download resource.
    You must register to access.
    Chapter 80: DENOSUMAB
    Open to download resource.
    Open to download resource.
    You must register to access.